Nurofen plus is a dual action painkiller which contains Ibuprofen and Codeine. This can be used for the relief of pain and ache including migraines, headaches, cramping period pain, dental pain, back pain, neuralgia, rheumatic pain, muscular pain and cold & flu symptoms. This medicine contains codeine which is an opioid and must be and should only be used for pain that is not relieved by other painkillers such as paracetamol or ibuprofen alone. They should be taken for a maximum of 3 days. If symptoms persist, you must consult your Doctor.